Alexei Popyrin has been eliminated from the ATP Masters 1000 in Indian Wells in the second round, beaten by eighth-seeded Hubert Hurkacz in straight sets.

Popyrin fought hard after dropping the opening set easily but was outclassed by Hurkacz 6-1 7-5.

The 22-year-old Australian broke serve for the first time when Hurkacz was attempting to close out the match at 5-4 in the second set, but was unable to complete the fightback.

Poland's Hurkacz is a three-time champion on the ATP Tour in 2021, including a maiden ATP Masters 1000 title at the Miami Open.

He will face Frances Tiafoe in the round of 32 after the American dispatched compatriot Sebastian Korda 6-0 6-4.

US Open champion Daniil Medvedev showed no signs of a grand slam hangover with a business-like 6-4 6-2 win over Mackenzie McDonald.

All aspects of the top-seeded Russian's game were clicking as he improved to 5-0 in head-to-head matches against the American.

"I'm actually really pleased, because usually I haven't played well in Indian Wells and I haven't been playing that well in practices before (the tournament)," Medvedev said.

"(I am) really happy with my performance. That's the most important (thing) no matter how I played before the tournament."

The 25-year-old Medvedev was sharp from the outset, breaking McDonald to open the match on a warm night in the Southern California desert.

Medvedev's ability to cover the court despite his towering frame, an aspect of his game that was on full display when he won a 44-shot rally, proved too much for the challenger, who never really pushed the tournament favourite.

He unleashed a blistering serve to McDonald's backhand on match point and the return sailed wide to end the affair.

The Russian ended world No.1 Novak Djokovic's shot at history last month by stopping his bid for a calendar year grand slam at Flushing Meadows.

Next up for Medvedev is Filip Krajinovic, who defeated Marcos Giron 7-6 (7-2) 7-5

Diego Schwartzman saved two match points to survive American qualifier Maxime Cressy 6-2 3-6 7-5.

The Argentine 11th seed recovered from a 15-40 deficit in the 10th game of the third set to break Cressy's serve before closing out the two hour and 38 minute thriller.

Briton's Daniel Evans outlasted Japan's Kei Nishikori 4-6 6-3 6-4, winning 80 per cent of his first-serve points in a strong defensive effort that saw him save 10 break points.

It was largely business as usual at the California tournament as 16th-seeded Reilly Opelka fired off 11 aces in a 7-5 6-3 win over Japan's Taro Daniel to reach the third round.

Canadian Vasek Pospisil was forced to retire in the first set against compatriot Denis Shapovalov, the ninth seed, while Norwegian sixth seed Casper Ruud made quick work of Spain's Roberto Carballes Baena 6-1 6-2.

Others to advance to the round of 32 were the seeded trio of Roberto Bautista Agut, Cameron Norrie and Grigor Dimitrov.