The banged-up Brisbane Lions have notched back-to-back AFL wins, Collingwood jolted in a 54-point loss that began with the late scratching of Nick Daicos.

The two-time defending premiers rocketed clear with five straight goals and, despite some wastefulness, kept the Magpies at bay before cantering clear 17.17 (119) to 10.5 (65) in their Easter Thursday Gabba fixture.

Big-name recruits Sam Draper (five clearances) and Oscar Allen (three goals) both impressed while Logan Morris (three goals) took nine marks to lead their forward-50 dominance and reverse a 52-point loss in the corresponding fixture 12 months ago.

The Magpies were rocked by the latest of injury withdrawals from star midfielder Daicos (calf), ruling him out of a game for the first time since he missed three-straight games late in the 2023 season.

He joined a casualty list that already included captain Darcy Moore and veteran Scott Pendlebury.

But the Lions entered well understrength too, with Hugh McCluggage, Harris Andrews, Darcy Gardiner, Dan Annable and Noah Answerth all sidelined by injury or suspension.

The Lions collected 131 contested possessions to the Magpies' 93 and had 20 marks inside 50 compared to the visitors' five.

Victory improved the Lions to 2-2, level with Collingwood, after their desperate defeat of St Kilda at Marvel Stadium on Saturday.

The Lions kicked 5.0 to surge 36 points clear in the second quarter, only to keep the Magpies in the match with a series of missed opportunities.

Roan Steele and Lachlan Sullivan kicked scrappy goals to compound those misses before Will Ashcroft (game-high 36 disposals) threaded the needle with a left-footed wonder goal that steadied the ship entering halftime.

Kai Lohmann (four goals), who kicked two in the first three minutes, had his third early in the second half before Logan Morris swung onto his right boot from 50m out and launched his second for a 37-point lead.

Again Collingwood hung tough, Jordan De Goey and Tim Membrey's goals energising the visitors and livening the contest again.

Morris set aside the disappointment of two missed set shots before the final break, taking his eighth mark and kicking straight for his third goal to begin the fourth quarter.

Zac Bailey followed suit moments later to create a 39-point buffer and all but put the contest to bed before the Lions piled on late goals.

West Coast pick-up Allen moved beautifully, leaping high for several pack marks, while former Essendon ruckman Draper's presence was felt in his best outing since returning from foot and Achilles injuries.

Dan McStay kicked four goals for Collingwood against his former club while Dan Houston had 32 touches and Josh Daicos gained 722 metres with his 25 possessions.